So many factors here. But I found one simple rule to be important when writing a spec and didn't get any joy until I started following it. And that is - whatever your genre - stick to it.

First few things I wrote were decent enough stories. But although they were basically thrillers, I could never resist a gag. So they became black comedy thrillers. Which is fine. But I didn't get anywhere until I put my mind to writing a straight genre piece. They're more marketable because people know how to sell it and what production companies will like it.

You mentioned Dramedy, which is an established genre, although it's mixed. And if it's awesome, you'll be good. Especially if it has a central concept people will quickly understand and want to read. But I think a good way to get noticed is to write a scary horror, or a funny comedy, or a dramatic drama ... you get the picture.

First meeting I had with a big production company - the development exec told me what got me there. Quite simply ... writing a thrilling thriller. Sounds obvious but still a rarity in his opinion.