The Good, The Bad, & The Baby by David Lee Webb - Comedy - A baby is born with the powers of speech and more than just a little attitude. A local Mafia Don believes in the prophesy of a second coming, and sets about shutting the baby up, before he and his army of 'God Soldiers' shut down the Dons rule of tyranny and oppression. 120 pages - pdf, format 8)

Log-line intrigued me here.

Front page is a little 'different', but okay.

Then it starts at page four - hope it's not my browser again... but I just got some blank pages after the title page, until p4.

Some quick observations.

'Ghetto' is a pejorative and probably not an appropriate way to describe a run down neighbourhood.
Everyone knows what a Harley sounds like so describing the sound seems redundant.
Even in a fantasy movie the OLD LADY is not believable. It would be sufficient to have her kick the smallest gobbiest youth in the balls and he is given a hard time by his laughing friends. Then Joe steps over the groaning youth.
OLD LADY is introduced as Old Lady (capitalisation needed)
East End swagger means nothing to a US audience. Swagger will do.
When Joe and Mary are talking about Gabe coming around when Mary makes the remark under her breath about the fact that they were screwing it would have more comedic value for you to use a quick SMASH CUT or FLASHBACK showing her and Gabe humping loudly on the bed.
I also couldn't work out why they needed to be cockneys in New York. Any value to that would be lost on a US audience, which is where you seem to be aiming.

You probably also should spend less time describing character's features. It's up to Casting to decide what colour hair a character has.
Why are they at the club? It seems they are only there to have a slapping contest. Nothing else seems to happen there except that and then they leave. The scene doesn't make any sense.
I'm afraid I only got a few pages in and honestly, I couldn't see where it was going.
Mary's pregnant, she and Joseph are looking for somewhere to sleep and they go to the inn. That's when you got to the point and everything before that seemed disconnected.

Your spacing seems a little out-of-whack. Which is actually a good thing since 120 pages is probably too long for a comedy.